![]() 3 On the other hand, lactoferrin binds to iron with a much higher affinity, and the ion is not known to be released until pH drops to around 2-3. ![]() Transferrin has a lower binding affinity to iron than lactoferrin does, and a slight dip below biological pH can trigger the protein to release its ion. 2 Transferrin, while in some cases able to prevent bacterial infection, is used more efficiently as an iron transport protein. 2 Lactoferrin is a member of the transferrin family, a group of proteins that bind specifically to iron and perform various functions in the body (see figure 2). Left: human protein, lactoferrin.Įnter to the scene lactoferrin, a iron-chelating protein that has an extremely high binding affinity for iron (III). Faecalis siderophore, ferric hydroxamate. 1 As a result of this mutual need, iron wars break out between bacteria and the human body, and each side has used scientific methods to more efficiently acquire this resource.įigure 1: Cartoon depicting the “iron wars” between human and bacterial iron-sequestering proteins. 1 However, humans aren’t the only organisms that need this ion as a nutrient source bacterial species depend on ions like iron to survive. While largely known for its rusting abilities, iron is also the catalyst for numerous metabolic processes, a binding agent in molecules like hemoglobin, and is even speculated to be a contributing ion to the early formation of macromolecules that eventually led to life forms. Wars can be started over metals like gold or silver, but the human body wages an internal war against pathogens on a daily basis over a seemingly insignificant metal: iron (see figure 1). Only time will tell how the streaming and comic book wars play out.Īrmor Wars is currently in development at Marvel Studios.\) Hollywood Studios are struggling to figure out what’s the best way to release content without overwhelming audiences or having content that falls by the wayside. If this decision to make Armor Wars a movie is any indication, then one can see that Marvel Studios is moving forward with an approach that will be more focused on quality than quantity. It's also worth noting that Marvel appears to be stepping away from episodic series and relying on Special Presentations instead. ![]() They need to show the world why this character matters. Hopefully, this decision will give Armor Wars more time to flourish, and considering this is War Machine's first leading role, it is a crucial creative decision on Marvel Studios' part. Seeing how Cheadle's character will be interacting with fully realized flight suits, it's smart that Marvel Studios chose to put more money and time behind this, especially considering the recent backlash over the work hours Marvel Studios' VFX artists endure. It's no secret that the budget for Marvel Studios' movies and shows is not the same. "Our Disney shows are awesome, and we love them, but the budgets are not the same as the features, that's not secret And when you're talking about a show that wants to be about seeing all the cool armors, and Don Cheadle interacting with all these armors, and the legacy of Tony Stark, that became cost-prohibitive to do as a show." “There were some great ideas that were coming out for that show, but that, to be quite honest, felt too big for that show," Moore said. Speaking on The Town with Matthew Belloni, producer Nate Moore explained why Armors Wars went from a TV series to a movie. RELATED: Black Panther: Wakanda Forever Producer Reveals There Was Only One Option To Replace T'Challa The upcoming project will play more into the political aspect of the world and what happens when Tony Stark's technology falls into the wrong hands. Marvel Studios' Armor Wars is set to take place following the climatic events of Avengers: Endgame and follows Iron Man's death. Fans recently learned why Marvel Studios decided to turn the project into a full-length film instead of the originally planned television series. Marvel Studios' Armor Wars will be War Machine's first leading role.
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